Hi,
You need the following the style.css file of your skin.
.pagelayout .addcontent{float: left; margin: 0 0 20px; }
.pagelayout .panelayout { clear: both; margin: 0 0 20px 0; padding: 0;}
.pagelayout .panelayout h2 {text-align: center; margin: 0 10px 10px 0;}
.pagelayout .regularpanes{margin: 0 auto; width: 630px; clear: both;}
.pagelayout .pane{float: left; clear: none;margin: 20px 0 20px 0; position: relative;}
.pagelayout .layoutcenter{margin: 20px 30px;}
.pagelayout .layoutalt1,
.pagelayout .layoutalt2{float: none;clear: both; width: 190px; margin: 0 auto; position: relative;}
.pagelayout .altlayoutnotice{margin-bottom: 20px;}
.pagelayout .panelistbox{position: relative; width: 190px;}
.pagelayout .pane select {width: 170px; margin-right: 10px;}
.pagelayout .layoutbuttons{right: 0; top: 5px; position: absolute;}
.pagelayout .layoutbuttons input{display: block; margin-bottom: 10px;}
If there are a lot of things out of whack with your skin, you should ask your designer to fix them because creating a skin for any CMS should account for things like this.
EDIT: Sorry, I need to clarify myself on that last remark. You are more than welcome to ask us for help and we will help you where possible. I just think your designer/skinner should deliver a finished product to you and that you have the right to complain to him if he didn't.
HTH,
Joe D.