Hi,
Since you are now hosted under .NET 4, you should upgrade to the latest version mojoPortal and use the package that is compiled for .NET 4, currently mojoportal-2-3-5-5-mssql-net40-deploymentfiles.zip.
There are also some differences in the asp.net menu under .NET 4 that may require some tweaks to your skin as discussed in this forum thread.
Best,
Joe