Hi,
When you go to site settings there is a link next to the skin dropdown that allows browsing the skins visually.
Note that all the included skins have adaptive column layout from 1 to 3 columns. It adapts based on what content you put into the content panes on the page. If there is content in left center and right it will use 3 column layout, if there is only content in the center it will use single column layout unless there is a menu on the left in which case it will use 2 column layout. So the main layout adapts automatically.
Its also possible to do column layouts within a single content region. Like the home page on this site appears to have 3 columns and then another full width article below the columns but in fact its really just one content instance so the main layout is really single full width column but inside that single column the content itself is formatted into columns. I could have achieve the columns using separate content instances but this approach of doing it within the single content instance reduces hits to the database.
Hope it helps,
Joe