Hey, thanks Joe. We're actually using MySQL built from source, and I verified in the web.config that all of the NeatUpload stuff is uncommented. In fact, other than merging your source repository changes into it, that file hasn't been changed by me in a very long time. Just to make absolutely sure, I took a look at System Info, and ASP.Net Info is showing " v4.0.30319 Running in Full Trust".
I looked at the Brettle.Web.Neat% DLLs, and the number of files and timestamps match in production and development.
Any other ideas?